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KMID : 1037620240110010057
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Pediatric Emergency Medicine Journal
2024 Volume.11 No. 1 p.57 ~ p.61
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Two adolescent cases of early use of Molecular Adsorbent Recirculating System for drug-induced fulminant hepatic failure
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Kim Seo-Yeon
Kim Beom-Joon
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Abstract
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Fulminant hepatic failure (FHF) is a rare but fatal disease with a 40%-80% mortality, often requiring liver transplantation, which is hard to perform in children. A therapeutic intervention alternative to liver transplantation is an extracorporeal artificial liver support system. Molecular Adsorbent Recirculation Systems?? (MARS) has emerged as a bridge therapy for adult FHF, whereas in pediatric FHF, there have been a small number of cases of implementing MARS. Recently, we witnessed the recovery of 2 teenagers with FHFs caused by acetaminophen and a diet aid. Both patients were treated uneventfully, with early use of MARS. These cases suggest that early use of MARS may be a promising therapeutic intervention in pediatric drug-induced FHF.
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KEYWORD
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Drug-Related Side Effects and Adverse Reactions, Liver, Artificial, Liver Failure, Acute, Liver Transplantation, Pediatrics
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